Visualizing Beta Cells in Patients With Hyperinsulinemic Hypoglycemia After Bariatric Surgery
In order to evaluate the difference in beta cell mass in patients with and without hyperinsulinemic hypoglycemia after Roux en Y gastric bypass (RYGB) investigators aim to compare quantitative PET imaging of the pancreas between these patient groups. These highly relevant data will provide investigators with more information on the possible role of beta cell mass in the mechanisms of hyperinsulinemic hypoglycemia bariatric surgery.
• Signed informed consent
⁃ Patients:
⁃ \- Persisting hyperinsulinemic hypoglycemia after a low-carbohydrate diet and/or insulin suppressive medication for one year.
⁃ Controls:
• RYGB at least 2 years ago
• Normal glucose levels before and after RYGB (fasting glucose between 4 and 6 mmol/l or HbA1c between 20 and 42 mmol/mol)
• Score ≤ 7 on Sigstad's scoring system (Table 1)
• Hypoglycemia excluded by 14-day continuous glucose monitoring
• Individual matched to HH group on age (± 5 years), sex and BMI at time of inclusion (± 2 kg/m2)